Specific Targeting of Treg Cells Using Immunomodulatory Nanoparticles as Adjuvant Therapy for Triple Negative Breast Cancer

Dual PD-1 and CTLA-4 Checkpoint blockade promotes antitumor immune responses through CD4 þ FOXP3 – cell–mediated modulation of CD103 þ dendritic cells

PA Beavis, MA Henderson, L Giuffrida, AJ Davenport, EV Petley, IG House, J Lai, K Sek, N Milenkovski, LB John, S Mardiana, CY Slaney, JA Trapani, S Loi, MH Kershaw, NM Haynes, PK Darcy

2018-09-01

Immunotherapy is widely accepted as a powerful new treatment modality for the treatment of cancer. The most successful form of imm..

Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

S Dushyanthen, ZL Teo, F Caramia, P Savas, CP Mintoff, B Virassamy, MA Henderson, SJ Luen, M Mansour, MH Kershaw, JA Trapani, PJ Neeson, R Salgado, GA McArthur, JM Balko, PA Beavis, PK Darcy, S Loi

2017-12-01

The presence of tumor-infiltrating lymphocytes in triple-negative breast cancers is correlated with improved outcomes. Ras/MAPK pa..

A multifunctional role for adjuvant anti-4-1BB therapy in augmenting antitumor response by chimeric antigen receptor T cells

S Mardiana, LB John, MA Henderson, CY Slaney, B Von Scheidt, L Giuffrida, AJ Davenport, JA Trapani, PJ Neeson, S Loi, NM Haynes, MH Kershaw, PA Beavis, PK Darcy

2017-03-15

Adoptive immunotherapy utilizing chimeric antigen receptor (CAR) T cells has demonstrated high success rates in hematologic cancer..

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

PA Beavis, MA Henderson, L Giuffrida, JK Mills, K Sek, RS Cross, AJ Davenport, LB John, S Mardiana, CY Slaney, RW Johnstone, JA Trapani, J Stagg, S Loi, L Kats, D Gyorki, MH Kershaw, PK Darcy

2017-03-01

Chimeric antigen receptor (CAR) T cells have been highly successful in treating hematological malignancies, including acute and ch..

A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer

CSM Yong, LB John, C Devaud, MH Prince, RW Johnstone, JA Trapani, PK Darcy, MH Kershaw

2016-06-07

While adoptive immunotherapy using chimeric antigen receptor (CAR)-modified T cells can induce remission of some tumors, the role ..

Reprogramming the tumor microenvironment to enhance adoptive cellular therapy

PA Beavis, CY Slaney, MH Kershaw, D Gyorki, PJ Neeson, PK Darcy

2016-02-01

The frontiers of cancer immunotherapy are extending in terms of both the range of cancer types that can potentially be targeted an..